General Pharmacology for the Forensic Toxicologist: July 2021

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DATES:

Tuesday, July 13th, 2021 from 11:00am ET - 5:00pm ET

Wednesday, July 14th, 2021 from 11:00am ET - 5:00pm ET

Thursday, July 15th, 2021 from 11:00am ET - 5:00pm ET

Registration: $600 per person
Groups of 5 or more: $450 per person

*All presentations must be attended to receive credit

Course Description

The Forensic Pharmacology course is brought to you in partnership by The CFSRE and Uptake. This unique online opportunity taught by Dr. Lionel Raymon, a clinical and forensic toxicologist whose expertise bridges the interface of pharmacology and toxicology with medical and behavioral sciences. Dr. Raymon is a gifted lecturer who draws on sensitive case experience and responsibilities of academic training to contribute to the rigor to methodology and peer review.

The format of the class is “live-on-line”. Dr. Raymon expects active participation of the class and dynamically orients the topics based on constant feedback and questions.

Who Should Register

Students, professionals, and anyone interested in furthering their knowledge of pharmacology.

Group Discounts

If you register 5 or more attendees from your business/organization, you are offered a reduced registration fee of $450.

Course Schedule

The aim overall is for the audience to find the “logical” in pharmacological!

The approach is didactic. There is no way to learn pharmacology drug by drug, whether in alphabetical order or in artificial sections. With 9000 + legal drugs, a brain meltdown is a guarantee, as is a propensity to consider addiction or suicide as an alternative to the study of pharmacology.

So, we will drive you through a more sensible approach, rooted in the understanding of normal physiology and biochemistry of select body function, their alteration by pathology, and the initial realization with this knowledge of what stimulating or blocking these pathways would result in. Then only, we will add on a pure memorization task: swallowing without gagging the name of a drug!

Three days, three different but complementary stories.

Day 1: Principles of Pharmacology

Our first day reviews key concepts of pharmacokinetics as they relate to absorption, distribution, metabolism, and elimination. Each section is illustrated with study questions to reinforce key points and the use of common equations. Pharmacokinetics of a single dose of drug are compared to chronic dosing.

The generalities relating pH of the environment and the pK of a drug are covered with emphasis on drug interaction, absorption, distribution to select compartment, such as the CNS, and renal elimination of weak bases and weak acids.

Comparing intravascular and extravascular drug administration will unmask concepts of bioavailability and bioequivalence.

Discussion of distribution will center around the effects of plasma protein binding and competition for it and will relate the apparent volume of distribution to dose and extrapolated concentration at time zero.

Metabolism will emphasize cytochrome P450, focusing on genetic polymorphisms and drug interactions through inhibition or through induction. More details are included this year on this rapidly evolving topic.

It is with the study of elimination that the main concepts of terminal half-life, constant of elimination k, and clearance are approached.

We will review zero and first order kinetic of elimination.

A series of workable equations are then used through selected study questions to practice this introduction to pharmacokinetics.

We finish day 1 with a rapid introduction to pharmacodynamics. Appreciation of affinity, efficacy and potency is gained from the study of log dose-response curves as well as the various forms of antagonism and agonism of receptors by drugs.

Day 2 and day 3 are entirely devoted to the pharmacodynamics of select drugs.

While day 2 aims at sharing the logical approach to pharmacology study in general, day 3 culminates with the application of days 1 and 2 to CNS drugs.

Day 2: Autonomic Nervous System Pharmacology

To study drugs requires strong bases in the normal physiology, anatomy, and biochemistry of our body.

Drugs merely stimulate or block existing biological pathways.

Unfortunately, the promiscuity of drugs with other receptors, enzymes, transporters, transcription factors results in long lists of understandable and predictable side effects. And many originate in altered autonomic responses. The historical understanding of our autonomic nervous system allows us to derive all these points readily.

Further, many of the DRE matrix signs and symptoms stem from autonomic responses elicited by the suspected drug causing impairment while driving.

The most important is an introductory chapter which sets up the autonomic nervous system, its chemistry, the receptors involved physiologically. We stress cardiovascular and eye autonomic responses.

Then two chapters follow, devoted to cholinergic and adrenergic pharmacology, respectively. A more in-depth review of where the receptors are and what they do is the critical approach to a clear expectation of agonists and blockers of cholinergic muscarinic, nicotinic, and adrenergic alpha and beta receptors.

Day 2 will allow the class to appreciate that pharmacology is grounded in a good understanding of our biology.

Knowing the name of a drug and what it binds to should allow us to derive its indications, side-effects, and importantly potential interactions with other medications.

Day 3: Central Nervous System Pharmacology

Impairment, addiction being topics of immense forensic relevance, we dedicate our last day to central nervous system drugs.

Due to the breadth of this section, we focus our efforts on GABAergic, opioid, and monoaminergic transmission. Adapting the autonomic nervous system review approach to the central nervous system will offer us a better understanding of agonists and blockers of these major neurotransmitters. Emphasis is placed on benzodiazepines, opioids, dopaminergic drugs, and antidepressants. If time allows, we will also approach stimulants and THC as medical marijuana.

Day 4: Rest!

Day 4 is entirely dedicated to your recovery from the harrowing 3-day trip and the worst high you ever experienced. But you will be on your own again, in your laboratory.

We are looking forward to meeting you online for our annual CFSRE/Uptake Forensic Pharmacology review!

 

Click the Enroll button below to register for the General Pharamcology Course!

83 seats available.
Price: $600.00
Buy 5 or more for $450.00 each
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